Kee YK, Nam BY, Jhee JH, et al. - Since corticosteroids act by binding glucocorticoid receptors (GCRs), researchers assessed the link between GCR expression and responsiveness to corticosteroid therapy in 33 patients with IgA nephropathy (IgAN), with mean age 43.9 ± 11.6 years (25 males and 8 females). Response to steroid treatment was evident in all patients, the occurrence of complete remission (CR) and partial remission was found in 14 (42.4%) and 18 (54.5%) patients, respectively. CR group had higher GCR expression, as confirmed by immunohistochemistry. Participants were observed for a median duration of 20.6 months, during which, disease progression was reported in 1 (7.1%) patient in the CR group vs 8 (42.1%) patients in non-CR group. Experts concluded that based on the degree of glomerular GCR expression in IgAN, responsiveness to corticosteroid may vary.