Cortellini P, et al. - In this investigation, researchers outlined specific designs for papilla preservation flaps (PPF) and minimally invasive surgery to be used in compromised molars and reporting evidence of principle data with 3–16 year follow up in severely compromised molars due to combined furcation and intrabony defects. Using periodontal regenerative devices, 49 individuals with furcated molars and deep intrabony defects have been treated with PPFs. According to results, 100% of maxillary and 92% of mandibular molars displayed improvements at 1 year. Over the 3-16-year follow-up, 1-year improvements could be maintained. Due to the combined presence of furcation involvement and deep intrabony defects, PPFs and periodontal regeneration can be applied and provide clinical benefits to severely compromised molars. These outcomes were achieved in well-maintained and compliant individuals in cases with an interdental peak of bone and gingival margin coronal to the entrance of furcation. To verify these findings, randomized controlled clinical trials with medium to long-term follow-up are required.