Body mass index, abdominal fatness, weight gain and the risk of urinary incontinence: A systematic review and dose-response meta-analysis of prospective studies
BJOG: An International Journal of Obstetrics and Gynaecology Aug 16, 2019
Aune D, et al. - Researchers addressed the correlation between adiposity and risk of urinary incontinence via performing a systematic literature review and dose-response meta-analysis of prospective studies on this topic. Inclusion of 24 prospective studies was done. Population-based studies showed summary relative risk (RR) per 5 kg/m2 increment in BMI of 1.20 and the respective value noted in pregnancy-based studies was 1.19; they observed summary RR of 1.18 per 10 cm increase in waist circumference and 1.34 per 10 kg of weight gain. Despite that the test for nonlinearity was significant for BMI, an approximately linear association was evident. For subtypes of urinary incontinence, the summary RR per 5 BMI units was 1.45 for frequent incontinence, 1.52 for severe incontinence, 1.33 for stress incontinence, 1.26 for urge incontinence, and 1.52 for mixed incontinence. Outcomes thereby revealed an association of increasing adiposity—as measured by BMI, abdominal fatness and weight gain—with an increased risk of urinary incontinence overall as well as with different subtypes.
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