Gelernter J, Sun N, Polimanti R, et al. - Researchers performed a genome-wide association study investigating a quantitative phenotype in 126,936 European American and 17,029 African American individuals in the Veterans Affairs Million Veteran Program based on maximum habitual alcohol consumption. For both populations, the lead locus was ADH1B, on chromosome 4: for the European American sample, rs1229984; for African American, rs2066702. Three additional genome-wide–significant maximum habitual alcohol consumption loci were identified in the European American sample: on chromosome 17, rs77804065, at CRHR1 (corticotropin-releasing hormone receptor 1); and on chromosomes 8 and 10. A meta-analysis of European American and African American samples was then performed. The significance of the associated region at CRHR1 increased to 1.02 × 10⁻¹³, and two additional genome-wide significant loci were identified, FGF14 (chromosome 13) and a locus on chromosome 11. Genetic correlation to other alcohol-related traits, smoking-related traits, and many others was observed in postgenome-wide association study analysis. In this study, five novel alcohol-use risk loci were identified; especially strong statistical support for CRHR1 was evident.