Tomasik J, Lago SG, Vázquez-Bourgon J, et al. – Patients with schizophrenia often demonstrate a higher risk for impaired glucose metabolism; however, the mechanism underlying this link remains to be elucidate. Researchers have conducted multiple studies in an effort to identify the determinants of insulin resistance (IR) in schizophrenia, with evidence suggesting that it cannot be fully explained by disease duration, symptom severity, medication effects, obesity, or hormonal stress axis activation, and other interacting factors are probably involved. Although investigators of family and genome-wide association studies have indicated a shared genetic vulnerability between schizophrenia and abnormal glucose metabolism, a direct correlation between schizophrenia genetic risk and insulin resistance has not been studied, at least to the knowledge of the current study authors. Thus, they examined the link between IR, schizophrenia polygenic risk, and treatment outcomes in first-episode, antipsychotic-naive patients with schizophrenia, and matched healthy individuals while also adjusting for demographic, lifestyle, and clinical factors.