Tablazon IL, Howard LE, De Hoedt AM, et al. - Among men with metastatic castration-resistant prostate cancer (mCRPC), an inquiry was made to determine factors predictive for skeletal-related events (SREs) and all-cause mortality, using the Shared Equal Access Regional Cancer Hospital database from 2000 through 2017. Researchers gathered data from 837 men with bone mCRPC at 8 Veterans Affairs medical centers. To fulfill the abovementioned goal, Cox proportional hazards models were used. An increased risk of SREs was observed in correlation with a shorter time from CRPC to the development of metastasis, shorter progression to CRPC, and visceral metastasis at the time of diagnosis of bone metastasis. An increased mortality risk was found to be related to 10 or more bone metastases, undergoing radical prostatectomy, shorter progression to CRPC, older age, higher prostate-specific antigen level at the time of diagnosis of metastasis, bone pain, and visceral metastasis. SREs were most strongly predicted by bone pain and mortality was strongly predicted by the number of bone metastases among men with bone mCRPC.