Huang X, Redfors B, Chen S, et al. - From the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction trial, researchers examined patients with non-anterior ST-elevation myocardial infarction (NA-STEMI) to determine clinical, electrocardiographic, and angiographic features that are predictive of 3-year mortality following primary percutaneous coronary intervention (PCI) in this population. A better prognosis was reported in NA-STEMI vs anterior STEMI but high-risk patient cohorts with NA-STEMI having substantial 3-year mortality may be identified. Older age (median > 59.0 years), diabetes, reduced LVEF (≤ 50%), Killip class ≥ 2, postprocedure TIMI flow 0–2 vs 3, renal insufficiency, and ST-resolution < 30% at 60 min post-PCI were all identified as independent predictors of increased 3-year mortality in NA-STEMI. The reported 3-year mortality rates for patients with 0, 1, 2, 3, and ≥ 4 of these risk factors were 1.8%, 2.3%, 3.1%, 6.1%, and 36.3%, respectively.