Zenesini C, Baldin E, Vignatelli L, et al. - In the Local Health Trust of Bologna, Italy, researchers explored the connection between the use of antidepressants as an indirect measure of depression and ensuing clinically diagnosed onset of Parkinson disease (PD). In this analysis, 199,093 person-years were exposed and 4,286,470 not exposed from 2006 to 2017. According to results, 51 PD patients were found in the exposed group and 556 individuals were found in the non-exposed group; an adjusted HR = 1.7 was seen. Investigators found that the use of antidepressants (as an indirect depression measure) is linked to the ensuing development of PD. They confirmed that the onset of motor symptoms in PD might be preceded by depression. The connection was stronger in males vs females, for subjects ≤ 65 years of age vs > 65 years and for those with fewer comorbidities. In the associations between antidepressant use and the onset of PD, age and gender were confounders.