Huang C, Song G, Wang H, et al. - A total of 308 individuals who underwent multiparametric MRI and RP with pelvic lymph node dissection (PLND), researchers examined the additional value of Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) scores when used in combination with clinical nomograms for the prognostication of lymph node invasion (LNI) in individuals with prostate cancer (PCa). In all, 20 individuals had LNI. All clinicopathological features and PI-RADSv2 scores were significantly correlated with LNI. However, only PI-RADSv2 scores and the percentage of positive cores were independently important, as demonstrated by multivariate analysis. The most reliable predictor was the PI-RADSv2 score. The threshold of PI-RADSv2 score was 5, which gave high sensitivity and negative predictive value. The AUC value progressed from 75.1 to 86.3% and from 79.2 to 87.9%, respectively, when PI-RADSv2 scores were combined with Briganti and Memorial Sloan Kettering Cancer Center nomograms. The decision curve analysis also exhibited that the two nomograms plus PI-RADSv2 scores enhanced clinical risk prediction of LNI. Therefore, in PCa, individuals with a PI-RADSv2 score < 5 were correlated with a very low risk of LNI. Moreover, the preoperative PI-RADSv2 scores could aid to enhance the exactitude of clinical nomograms for prognosticating pelvic LN metastasis at radical prostatectomy.