Zanetti HR, et al. - In people living with HIV, researchers conducted this randomized, double-blind, placebo-controlled clinical trial to assess the impacts of exercise training (ET) combined with statins. They assigned 83 patients living with HIV to placebo (PL), statins (STA), placebo + ET (PLET) or statins + ET (STAET) groups. For this investigation, 10 mg of rosuvastatin were given to volunteers assigned to STA and STAET groups. Compared with PL group, there was a reduction in total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-c), C-reactive protein, fibrinogen, interleukin (IL)-1β and right carotid intima-media thickness (cIMT) in the STA, PLET, and STAET groups. In the STAET group, TC, TG, LDL, IL-1β, IL-6, and IL-8 levels and left and right cIMT were reduced while HDL-c levels increased vs the STA and PLET groups. The authors concluded that ET and statin combinations are helpful in improving lipid and inflammatory profiles, lowering CVD markers and enhancing Doppler ultrasound results, muscle strength, and cardiorespiratory fitness in individuals living with HIV.