Carey RN, et al. - Among men and women aged ≥ 50 years residing in Australia, the links between lifestyle factors (smoking, physical activity, alcohol consumption, fruit and vegetable consumption, and body mass index) and occupational factors (labor force status, occupation, and participation in shift work) and participation in colorectal cancer (CRC) screening were comprehensively assessed for the first time ever in this study. The likelihood of reporting ever-screening for CRC was lower among female current smokers, less physically active men, and men who reported no alcohol intake but reported eating more vegetables. Engagement in more healthy behaviors was associated with greater participation in CRC screening, suggested the possible significance of an individual's pattern of lifestyle behaviors in determining screening participation.