Hiremath S, et al. - In this study, researchers compared the use of alpha-blockers (ABs) with other blood pressure (BP)-lowering drugs in terms of the risk of hypotension and related adverse events among women (aged ≥ 66 years) with hypertension. A composite of hospitalizations for hypotension and associated events (syncope, fractures, and falls) within 1 year was assessed as the primary outcome. With AB and with other BP-lowering medications, the estimated crude incidence rate of hypotension and related events was 95.7 and 79.8, respectively. For hypotension and syncope, a higher risk was observed, with no difference in falls, fractures, adverse cardiac events, or all-cause death. Overall, a higher risk of hypotension and hypotension-related events was observed in relation to treatment with ABs vs other BP lowering agents among participants. Exercising caution while using ABs was recommended, even when these are used as add on treatment for hypertension.