Paik JM, et al. - In this prospective study, researchers explored the connection between body mass index, waist circumference, and vertebral fracture (VF) risk in women. This investigation was carried out in 54,934 Nurses’ Health Study participants. Five hundred thirty-six VF cases (2002 to 2014) were included in this analysis. Findings suggested an independent association of greater lean body mass with lower VF risk. Larger waist circumference was associated with a higher risk of VF independently. These results indicated that the distribution of fat may be a significant predictor of VF and that avoiding central adiposity and retaining muscle mass may result in reduced risk of VF in elderly women.