Taher R, et al. - In this retrospective cross-sectional analysis with 140 patients (mean age 50.7 ± 12.9 years), researchers explored the connection between elevated serum uric acid (SUA) and peripheral endothelial dysfunction (PED). The study sample consisted of patients who were referred to the Mayo Clinic between 2006 and 2014 for routine cardiovascular assessment and who had an evaluation of Reactive Hyperemia Peripheral Arterial Tonometry (index <2 consistent with PED). In women who are otherwise at low risk for CVD, high normal SUA levels are related to PED. SUA is, therefore, a promising circulating biomarker that can be used to aid risk stratification in female patients with chest pain and/or those undergoing CVD risk assessment. This relationship was only seen in women.