Nonterah EA, et al. - Researchers investigated the factors related to carotid intima-media thickness (CIMT), a marker of sub-clinical atherosclerosis, in adults aged 40 to 60 years from Burkina Faso, Kenya, Ghana, and South Africa enrolled in the cross-sectional H3 (Human Hereditary and Health) in Africa’s AWI-Gen (African-Wits-INDEPTH partnership for Genomic) study. Higher CIMT was seen in those from Ghana and Burkina Faso vs other sites. A higher CIMT was reported in relation to age, body mass index, systolic blood pressure, low-density lipoprotein cholesterol, and male sex. Men showed higher CIMT in relation to smoking. Findings revealed inverse link of high-density lipoprotein cholesterol, alcohol consumption, and HIV with CIMT. Since the prevalence of cardiovascular diseases risk factors in sub-Saharan Africa is increasing, the possibility of atherosclerotic diseases becoming a chief pan-African epidemic is suggested if hypertension, obesity, and smoking are not prevented. Since a lower prevalence of CVD risk factors in was seen in those living with HIV, the HIV care cascade could offer an efficacious resource for cardiovascular disease prevention and control among people living with HIV.