Tait JL, et al. - In this cross-sectional study including 268 men and women aged ≥65 years residing independently in retirement communities in Melbourne, Australia, researchers examined the links between systemic inflammatory markers [interleukin (IL)-4, IL-6, IL-1β, IL-8, IL-10, tumor necrosis factor-α, and high sensitive C-reactive protein] and neurological markers (amyloid β (1-40) and amyloid β (1-42), brain derived neurotrophic factor, insulin-like growth factor-1 and vascular endothelial growth factor) with well-being and health-related quality of life (HR-QoL). No consistent evidence suggesting a link between circulating inflammatory or neurological markers and key physical or mental HR-QoL domains or overall well-being were found in this study on elderly people living in independent living retirement communities. This indicates the possible non-efficacy of these biomarkers as predictors in relatively healthy communities, as well as suggests the possible more benefits of these in frail or clinical populations.