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Occupational exposure to endocrine disrupting chemicals and other parental risk factors in hypospadias and cryptorchidism development: A case-control study

Journal of Pediatric Urology Jul 19, 2019

Sastre BE, et al. - Through a case-control study performed on infants (n=210) between 6 months and 14 years of age diagnosed with hypospadias or cryptorchidism who visited the hospital over a period of 18 months, and controls (n=210) of infants within the same range of age and without any urological disorders, experts examined the correlation between endocrine disrupting chemicals (EDC, exogenous agents that have the ability to change the endocrine system functions, including the regulation of developmental processes) exposure and other parental factors in the aetiology of hypospadias and cryptorchidism. Correlations were discovered amongst progressed maternal age, mother´s consumption of anti-abortives and other drugs during pregnancy, maternal and paternal occupational exposure to EDC, fathers smoking and with urological disorders. Maternal and paternal high education level could be protective of cryptorchidism. For the whole sample, for cryptorchidism, and for hipospadias, the discriminatory correctness of the models was moderately high. Hence, progressed age, some parental occupational exposure to EDC, some drugs intake, smoking and the father´s history of urological disorders were concluded to elevate the risk and prognosticate the developments of the above mentioned malformations. Furthermore, to evaluate relationships among people with EDC occupational exposures and drugs and these malformations, studies with more extensive samples sizes are required.
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