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Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study

PLoS Medicine Jul 10, 2019

Al-Jebari Y, et al. - In this nationwide register study involving 2,027,997 people, researchers ascertained if anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional congenital malformation (CM) risk. One hundred eighty-four had a CM among children fathered by men with TGCC (n = 4,207). Compared to children fathered by men without TGCC, the risk of malformations was higher among children of fathers with TGCC. In children of men with TGCC treated with radio- or chemotherapy, no additional increased risk of CMs was noted. Paternal TGCC per se was, however, linked to modestly increased risk for offspring malformations. Clinically, patients concerned can be reassured by this data.
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