Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study
PLoS Medicine Jul 10, 2019
Al-Jebari Y, et al. - In this nationwide register study involving 2,027,997 people, researchers ascertained if anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional congenital malformation (CM) risk. One hundred eighty-four had a CM among children fathered by men with TGCC (n = 4,207). Compared to children fathered by men without TGCC, the risk of malformations was higher among children of fathers with TGCC. In children of men with TGCC treated with radio- or chemotherapy, no additional increased risk of CMs was noted. Paternal TGCC per se was, however, linked to modestly increased risk for offspring malformations. Clinically, patients concerned can be reassured by this data.Go to Original
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