Dickerman BA, et al. - In this prospective analysis of 1832 men in the Age, Gene/Environment Susceptibility–Reykjavik study, researchers assessed the risk of clinically relevant prostate cancer in relation to objectively measured body fat distribution. Baseline computed tomography imaging of fat deposition, bioelectric impedance analysis, and measurement of body mass index (BMI) and waist circumference were performed from 2002 to 2006. The risk of advanced and fatal disease was observed in all men in relation to visceral fat and thigh subcutaneous fat, respectively. Both advanced and fatal disease were reported in relation to visceral fat among men who were leaner based on BMI. A higher risk of advanced and fatal disease was reported in relation to BMI and waist circumference. Findings revealed no link of any of the adiposity measures with total or high-grade disease.