Erim DO, et al. - In prostate cancer survivors, researchers determined the prevalence and predictors of depression using a population-based cohort. Participants were North Carolinian prostate cancer survivors who participated in the North Carolina–Louisiana Prostate Cancer Project (n=1,031) and underwent prospective observation in the Health Care Access and Prostate Cancer Treatment in North Carolina study (n=805). In the year of cancer diagnosis, 38% was the prevalence of probable depression, which declined to 20% 6 to 7 years later. African American race, unemployment, low annual income, younger age, recency of cancer diagnosis, past depression, comorbidities, treatment decisional regret, and nonadherence to exercise recommendations were identified as risk factors for probable depression. For prostate cancer survivors, depression has been recognized as a major challenge, especially in the first 5 years following cancer diagnosis. A link between treatment decisional regret and probable depression is shown for the first time in this study.