Brouwer AF, et al. - Using data from the Michigan HPV and Oropharyngeal Cancer Study, researchers analyzed a college-age cohort of both men and women to study the links between human papillomavirus (HPV)-vaccination and sexual behavior, considering vaccination status and substance use. Overall 241 college-aged men and women were analyzed. After controlling for age, race, sex, and substance use, no significant link was found between HPV vaccination status and an increased chance of sexual debut, reduced age of sexual debut, or an increased number of sexual partners. The identified independent predictors of sexual behavior were race or alcohol use. For both males and females, concerns regarding the impact of the HPV vaccine on sexual behavior are likely unfounded. In addition to informing and strengthening physician suggestions, these findings can help in increasing vaccine acceptability, as well as in attenuating the burden of HPV and HPV-associated cancers in the US.