Wan EYF, et al. - Researchers examined the correlation between systolic blood pressure, cardiovascular disease, and chronic kidney disease in this study. They determined the risks of cardiovascular disease and chronic kidney disease associated with systolic blood pressure by Cox regression using baseline and repeated systolic blood pressure (average of all systolic blood pressure measurements in the past 5 years). The study included a population-based cohort of 267,469 adult patients with hypertension but without diabetes mellitus, cardiovascular disease, or chronic kidney disease. Over 1.4 million person-years follow-up (median 6 years), diagnosis of 29,500 cardiovascular disease cases and 30,993 chronic kidney disease events were recorded. Baseline systolic blood pressure was noted to have a J-shape association with risks of cardiovascular disease and chronic kidney disease. The possible relevance of very low single measurement of systolic blood pressure as a potential indicator for poor health was suggested; however, there appeared no threshold for usual systolic blood pressure.