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Low levels of pannexin-1 in Behçet’s syndrome

International Journal of Rheumatic Diseases Jun 27, 2019

Şahin A, et al. - Forty-six patients who were under follow-up for Behçet's syndrome (BS, a chronic, multisystemic and inflammatory syndrome) in the Sivas Cumhuriyet University Medical Faculty Department of Internal Diseases, Rheumatology Unit, between January 2017 and June 2017 were included by the researchers distinguish the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects in order to assess their level in patients and their relationship with the clinical findings. Patients were randomized in healthy controls (HC) and BS groups. No statistically significant differences could be recognized after comparing serum caspase-3, caspase-9 and caspase-14 levels in subjects with BS and in the HC group. However, in the BS group, serum pannexin-1 levels were observed as statistically significantly lower.
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