Guo X, et al. - In this investigation, researchers examined the impact of two commercially available hemostatic agents (ie, collagen sponge and oxide cellulose) on early healing of the extraction socket. Bilateral maxillary first molars were extracted in a murine model and the sockets were filled with or without hemostatic agents. In vitro studies have also been designed to examine the impact of agents on pH dynamics and cell viability. According to results, both agents postponed early socket healing but with distinct patterns. Both materials delayed proliferation and osteogenic differentiation of cells. In addition, in the haemostatic agent groups, apoptosis of periodontal ligament cells was present. Both agents attribute these effects to the compression of the periodontal ligament, the acidic niche caused by oxide cellulose, and the agents' intense external body reaction and inflammatory response. Overall, the investigators concluded that hemostatic agent placement delays early socket extraction healing through different biological mechanisms.