Naumova EA, et al. - In this single-center, randomized, parallel in vivo trial with a three strata block design, researchers examined the dynamics of fluoride bioavailability in salivary compartments (supernatant and sediment) up to 2 hours after standardized toothbrushing with F-bioactive glass dentifrice and compared it with the fluoride bioavailability in salivary compartments after application of dentifrices containing sodium fluoride (NaF) and amine fluoride (AmF). Compared to fluoridated bioactive glass, the increase of bioactive fluoride in supernatant saliva was higher after application of NaF or AmF. Investigators found that toothbrushing with bioactive glass dentifrices containing fluoride had a beneficial effect on the bioavailability of fluoride within 2 hours. Fluoride that contains bioactive glass is a new area for caries prophylaxis investigation. Further consideration should be given to the bioactive potential effect on tooth remineralization.