Blagojevic-Bucknall M, et al. - Via a population-based cohort of 1,878 participants who had joint pain at baseline lasting ≥3 months and who were aged ≥50 years, investigated modifiable predictors of pain interference and estimated maximum potential gain from intervention. The onset of pain interference after 3 years, was independently and significantly associated with inadequate joint-specific pain control, insomnia and infrequent walking. If clinical and public health interventions could target pain management and insomnia and promote an active lifestyle, there would be a chance for the moderate reduction of the onset of pain interference from joint pain in the over-50s. However, even after the assumption that these factors could be eliminated, prevention of most of the onset of significant pain interference in the over-50s could be carried out.