Talaulikar VK, et al. - Via a 10-year mixed (retrospective and prospective) longitudinal study in 17 women with transfusion-dependent beta thalassaemia major (BTM), the contributors sought to compare the markers of ovarian reserve in women with transfusion-dependent BTM over a period of ten years with healthy women from a control population. Lower serum AMH levels, estradiol levels and antral follicle in women with BTM were noted. Low AMH levels in both groups of women (with and without hypogonadotropic hypogonadism) with a background of BTM were also observed. Hence, lower levels of serum AMH level and AFC suggesting a direct impact of the disease activity or iron overload on the ovary were concluded by the observers in women with transfusion dependent BTM as compared to age-matched healthy controls.