Nocon CC, et al. - In locally advanced laryngeal cancer patients, researchers assessed the survival benefit of total laryngectomy (TL) after induction chemotherapy. This is a retrospective study using the National Cancer Database that captures in the United States >80% of newly diagnosed head and neck squamous cell carcinoma cases. The study sample consisted of patients diagnosed with advanced stage laryngeal squamous cell carcinoma between 2004 and 2013 (n = 5649) who received either TL (n = 4113; 72.8%) or induction chemotherapy followed by either radiation therapy (n = 1431) or TL (n = 105). No survival differences were found between TL and induction chemotherapy followed by TL. In patients with locally advanced larynx cancer who fail induction chemotherapy and undergo TL, larynx preservation can be attempted without compromising survival.