Hakim J, et al. - In nonsexually active (NSA) adolescents, researchers analyzed the incidence, presentation, and management of tubo-ovarian abscesses (TOA). Self-reported NSA females aged < 21 years diagnosed with TOA were assessed for this retrospective chart review. Sixteen NSA females (mean age at diagnosis was 14.6 ± 1.8 years) met the criteria for inclusion, with one patient having two separate TOAs. Abdominal pain, fever, and vomiting were included presenting symptoms. All cases received intravenous antibiotics, and outpatient oral antibiotics continued to be used in 88% of cases. Although uncommon in females with NSA, patients with underlying comorbidities may be at increased risk of developing TOA. Even in females with NSA, providers should consider the diagnosis of TOA.