Dalby M, et al. - In this prospective, randomized, parallel-group surgical clinical trial, researchers compared the long-term safety and effectiveness of two operation methods for late in-the-bag intraocular lens (IOL) dislocation. During a 3-year period, 104 patients (104 eyes) were randomly assigned to one group for IOL repositioning by scleral suturing (n = 54) or one for IOL exchange by retropupillary fixation of an iris-claw IOL (n = 50). The study sample consisted of 66 patients (63%) who finished the 2-year follow-up and corrected distance visual acuity 2 years after surgery was the main outcome measure. Between IOL repositioning and IOL exchange 2 years after surgery, no significant differences were found in visual acuity. From a long-term perspective, both techniques were similarly effective and secure and are both deemed acceptable treatments. There have been no cases of endophthalmitis or retinal detachment.