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Sex differences in presentation and outcome after an acute transient or minor neurologic event

JAMA May 27, 2019

Yu AYX, et al. - In this prospective cohort study involving 1648 patients, researchers assessed sex differences in the symptoms, diagnoses, and outcomes of patients with acute transient or minor neurologic events. In addition, they evaluated the connection between presenting symptoms (focal vs nonfocal) and clinical diagnosis. They found no significant sex differences for presenting symptoms. Patients with focal and nonfocal symptoms were more likely to receive a diagnosis of cerebral ischemia vs those with no focal neurologic symptoms, but the risk was highest among patients with focal symptoms only. Despite similar symptoms at present, women with acute transient or minor neurological events were more likely to be diagnosed with stroke mimics than men, but the risk of stroke recurrence or stroke, myocardial infarction or death within 90 days of the event was similar among women and men. These outcomes call attention to potential missed opportunities among women for stroke prevention and other adverse vascular events.
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