Lui RN, et al. - Using data from the International Agency for Research on Cancer, experts examined the temporal change of incidence rates for colorectal cancer (CRC) in different nations worldwide. Specifically, they compared incidence rates between age groups, defining young-onset CRC cases as those aged < 50 years. For people aged < 50 years vs those aged > 50, a faster rate of increasing annual percentage change was reported in Australia (+1.10% vs -0.35%), Brazil (+9.20% vs +5.72%), Canada (+2.60% vs -0.91%), China - Hong Kong (+1.82% vs -0.10%), China - Shanghai (+1.13% vs -2.68%), Japan (+2.63% vs +0.90%), the United Kingdom (+3.33% vs +0.77%), and the United States (+1.98% vs -2.88%). Across the globe, an increasing incidence of young-onset CRC was reported in many regions.