Berton G, et al. - In this study with 589 patients admitted with acute coronary syndrome (ACS), researchers sought to determine if a link exists between baseline plasma lipid levels during ACS and malignancy in long-term. The participants were discharged alive and were evaluated for plasma lipid levels on the first morning post-admission. A follow-up was performed for 17 years or until death. At enrollment, 571 patients were free from malignancy. During follow-up, 99 (17.3%) developed malignancy and 75 (13.1%) died because of it. The detected plasma levels of total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides were lower in patients with malignancy vs those without malignancy. In this long-term prospective study, findings revealed an independent association of neoplasia onset and mortality with low plasma TC and LDL levels at admission for ACS.