Wu L, et al. - Researchers utilized data from the Genotype-Tissue Expression Project in this transcriptome-wide association study, to identify new prostate cancer genetic loci and possible causal genes at already identified risk loci. This study included 79,194 cases and 61,112 controls of European ancestry. For 137 genes, significant links at P < 2.61×10-6, a Bonferroni-corrected threshold, were found. Of these, nine continued to be significant at P < 2.61×10-6 when all known prostate cancer risk variants in nearby regions were adjusted. They found that 94 of the 128 left associated genes have not yet been identified as potential target genes at known loci. Fourteen genes were silenced and a consistent impact of many on viability and colony-forming efficiency was evident in three cell lines.