Chapman BV, et al. - Via this retrospective analysis of 249 women with FIGO 2009 stage IIIC endometrial cancer, researchers sought to determine the optimal adjuvant treatment regimen for cases with endometrioid and non-endometrioid node-positive endometrial cancer. The participants had undergone surgical staging followed by treatment with external beam radiotherapy (RT), chemotherapy (CT), or a combination of CT + RT. The Kaplan-Meier method was used to calculate survival rates. In patients with all subtypes of node-positive endometrial cancer, excellent outcomes were obtained with combined-modality therapy including adjuvant external beam pelvic radiotherapy. In women with non-endometrioid endometrial cancer, adjuvant chemoradiotherapy offered the most pronounced disease-specific survival benefit.