Li XD, et al. - Because a vital component of the centrosome involved in regulating organelle activity during the cell cycle is centrosomal protein (CEP)-72, the function of which in the case of human cancer is not yet clear, researchers examined the expression dynamics of CEP72 and its clinical impact in a large cohort of bladder tissues. Investigators found that urothelial carcinoma of the bladder (UCB)'s CEP72 overexpression was linked to the acquisition of an aggressive phenotype that was associated with poor prognosis. CEP72 has been shown to induce UCB cell aggressiveness by up-regulating a significant downstream target, the serpin family member 1 gene (SERPINE1), which ultimately leads to increased invasiveness of cancer cells. In particular, overexpression of CEP72 was associated with a significant increase in the response element of cAMP–binding protein binding at the promoter of SERPINE1, resulting in increased transcription of SERPINE1. The potential use of CEP72 as a therapeutic tool for UCB is suggested by such observations.