Ceklic L, et al. - Patients with diabetic macular oedema (DME) under continuous anti-vascular endothelial growth factor (VEGF) therapy were examined for the prevalence and impact of ganglion cell layer cysts (GCLC). Researchers determined the impact of GCLC cysts among a total of 110 eyes of 110 DME patients (mean age 64 ± 10 years) via analyzing the retrospectively collected data regarding their clinical findings and spectral domain optical coherence devices of baseline visits and follow-up after 12–24 and 36 months of DME patients under continuous anti-VEGF therapy. Outcomes revealed 68 ± 23.4 μm less central retinal thickness (CRT) decrease in eyes with GCLC than eyes lacking GCLC. GCLC remained a statistically significant factor for the outcome parameter CRT, but missed statistical significance for best-corrected visual acuity, in the linear mixed effect models including external limiting membrane disruption, disintegration of inner retinal layer and epiretinal membrane.