Li X, et al. – Researchers investigated the predictive value of frailty index (FI) for all-cause and cause-specific mortality in nearly 43,000 participants from the Screening Across the Lifespan Twin Study with up to 20 years’ mortality follow-up. They also evaluated the proportion of all-cause and cause-specific deaths responsible for raised levels of frailty. Higher risks of all-cause, cardiovascular disease, and respiratory-related mortality independent of familial effects were attributable to increased FI. A greater risk at midlife vs older age was also attributed to elevated FI. Furthermore, increased FI has a substantial population mortality effect that is greatest through midlife until 80 years of age, noted the investigators.