Hopman WM, et al. - From the Canadian Multicentre Osteoporosis Study, researchers examined the results of participants aged ≥ 50 years with 10-year follow-up for the association of health-related quality of life (HRQOL) with osteoporosis in the absence of fracture. In addition, they also assessed changes in HRQOL over time. Participants had completed the SF-36, a detailed health questionnaire, and measures of bone mineral density (BMD) at baseline and follow-up. Via analyzing baseline data of 5,266 women and 2,112 men—as well as 10-year follow-up data from 2,797 women and 1,023 men—they noted a substantial reduction in HRQOL in women and men with self-reported and/or BMD-confirmed osteoporosis, even in the absence of fragility fracture. Thus, they recommended thoroughly reviewing HRQOL even prior to fracture in order to develop appropriate interventions for all stages of the disease.