• Profile
Close

Effect of sunscreen application under maximal use conditions on plasma concentration of sunscreen active ingredients: A randomized clinical trial

JAMA May 12, 2019

Matta MK, et al. - In this randomized clinical trial involving 24 healthy candidates, researchers ascertained if the active ingredients (avobenzone, oxybenzone, octocrylene, and ecamsule) of four commercially available sunscreens are absorbed into systemic circulation. They found that maximum plasma concentrations for the active ingredient avobenzone were 4.0 (60.9%), 3.4 (77.3%), 4.3 (46.1%), and 1.8 (32.1%) ng/mL, respectively, for two different sprays, a lotion, and a cream. The investigators also noted that the application of thse four sunscreens under maximum conditions of use resulted in plasma concentrations exceeding the FDA threshold for the possibility of waiving some non-clinical sunscreen toxicology studies. Rash was the most common adverse event, which developed with each sunscreen in one participant. These outcomes, however, did not suggest that people should refrain from using sunscreen. The sunscreen ingredient systemic absorption supports the need for further studies to determine the clinical significance of these findings.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free.
  • 55 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Unlimited access to original articles by experts
  • Nonloggedinlock icon
    Secure: we never sell your data
  • Signing up takes less than 2 mins
Try M3 India / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay