Girard P, et al. - In this prospective study involving 5,429 participants living in 175 nursing homes (NHs), researchers examined the association of acetaminophen use in a large sample of older adults with mortality and major cardiovascular events (strokes and myocardial infarction [MI]). No associations were found between intake of acetaminophen and mortality or MI risk. Despite old age, polypharmacy, and polymorbidity, acetaminophen was found to be safe for most of the NH study population, but not all. Managing pain in NHs is a health priority and as a first-line analgesic, acetaminophen remains a good therapeutic choice. More studies on older patients with diabetes, however, are needed.