Lee JW, et al. - Among individuals with hypercholesterolemia from the National Health Insurance Service-National Health Screening Cohort (2002-2015), researchers assessed site-specific risk of colorectal cancer in relation to statin use. Based on medication possession ratio, they categorized statin users as either high and low users. Subjects who did not take statins during the entire follow-up period were considered as statin non-users. A total of 17,737 statin users and 13,412 statin non-users were followed up for a median of 12.7 years. Lower risk of overall colorectal cancer, particularly proximal colon cancer in men and rectal cancer in both sexes, was observed in relation to high statin users with hypercholesterolemia.