Ran T, et al. - Because previous researchers have investigated the economic effects of colorectal cancer (CRC) screening, investigators of this systematic review of 33 studies sought to provide up-to-date evidence of CRC screening strategies' cost-effectiveness by answering three research questions. They extracted, or calculated (if necessary), per-person costs, life years (LYs), and/or quality-adjusted LYs for all research questions, as well as the incremental costs per LY gained or quality-adjusted LY gained vs the baseline strategy. To answer research question 2, the net monetary benefit approach was used. Compared with no screening, annual and biennial guaiac-based fecal occult blood tests, annual and biennial fecal immunochemical tests, colonoscopy every 10 years, and flexible sigmoidoscopy every 5 years were cost effective. According to findings, common CRC screening strategies and computed tomographic colonography continued to be cost effective vs no screening in an updated review. Studies from different regions had discrepancies that could be associated with model types or assumptions of models.