Relation of cardiovascular events and deaths to low-density lipoprotein cholesterol level among statin-treated patients with atherosclerotic cardiovascular disease

The American Journal of Cardiology Apr 07, 2019

Chamberlain AM, et al. - Authors assessed consequent cardiovascular events and deaths by low-density lipoprotein cholesterol (LDL-C) level in 1,854 subjects with atherosclerotic cardiovascular disease (ASCVD) getting moderate- to high-intensity statins. They observed the rates per 100 person-years to be 10.51, 9.57, and 11.40 for LDL-C < 70, 70 to < 100, and ≥ 100 mg/dL, respectively, at initial follow-up 90 days after index ASCVD event. A significantly higher hazard ratio for cardiovascular event and/or death for subjects with LDL-C ≥ 100 mg/dL vs those with LDL-C < 70 mg/dL was evident, after adjusting for age, sex, and past diagnoses of ASCVD, diabetes, hypertension, heart failure, and chronic kidney disease.

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