Zhang MA, et al. - In this case-crossover study conducted from 2003 to 2012, authors examined 724 individuals to define the correlation between omega-3 polyunsaturated fatty acid (n-3 PUFA) consumption (dietary or supplemental) and risk of gout flares. They reported 22% of participants consumed some form of n-3 PUFA (supplements: 4.6%; dietary fatty fish: 19%) in the previous 48 hours. They observed that 85% of participants had gout as defined by the 1977 Preliminary ACR classification criteria for acute gout. When adjusted for total purine intake, they found an association of dietary n-3 PUFA-rich fish consumption with lower risk of recurrent gout flares, but not n-3 PUFA supplementation alone.