Cabral M, et al. - Via analyzing data from 1147 subjects from a population-based cohort, researchers assessed the longitudinal link between the cumulative exposure to adiposity and low–grade inflammation from adolescence into early adulthood. At 13, 17 and 21 years of age, body mass index (BMI), body fat percentage (BF%), waist circumference (WC), and waist-to-height ratio (WHtR) and high-sensitivity C-reactive protein (hsCRP) of the participants were determined and standardized for each wave. The link between the difference in adiposity between two consecutive assessments (13 to 17 and 17 to 21-years-old), adjusted for previous adiposity and hsCRP levels, sex, parental education, leisure-time physical activity and fruits and vegetables intake, was determined by the final model. Low-grade inflammation was found to be significantly and longitudinally influenced by the accumulation of adiposity. Compared with both previous adiposity and hsCRP levels, the change in adiposity from consecutive study waves demonstrated a stronger influence on final hsCRP levels.