Laitman BM, et al. - A sum of 519 free tissue transfer patients were studied to estimate the result of core body temperature on free tissue flap consequences in candidates undergoing microvascular reconstruction. They documented demographic information, mean/minimum/maximum body temperatures as well as the presence of flap complications like venous thrombosis, arterial insufficiency, flap death, wound infection/dehiscence, fistula, chyle leak, and hematoma/seroma. They noted the presence of ≥1 flap complication in 19.8% of subjects. They also reported the average temperature for all subjects, 36.12 ± 0.84 °C, with a minimum at 34.43 ± 0.97 °C and maximum at 37.24 ± 1.23 °C. They found a significant correlation between flap complications and mean intraoperative temperature after controlling for several factors like tumor stage, radiation, diabetes, BMI, age, sex, and flap type. They suggested improvement in flap outcomes due to mild relative hypothermia.