Chaisson LH, et al. - Among people living with HIV (PLWH) initiating antiretroviral therapy (ART), researchers examined if C-reactive protein (CRP) concentrations could predict poor outcomes. They analyzed 1,293 patients (median CD4⁺ T-cell count 181 [interquartile range 82–278]) from two HIV clinics in Uganda. Death was reported in 23 (1.8%) patients within 3 months, including 19 of 355 (5.4%) with elevated point-of-care (POC) CRP and four of 938 (0.4%) with nonelevated POC CRP. Findings suggest that higher pre-ART POC CRP concentrations are connected to early mortality and opportunistic infections among PLWH with advanced HIV. Identification of patients at high risk for poor outcomes using POC CRP testing pre-ART may help reducing mortality.