Kemp JP, et al. - In adolescents, insulin and adiponectin levels are linked to cortical bone size, which infers factors linked to fat metabolism directly influence skeletal development, so researchers analyzed connections between a metabolic screen concentrating on fat metabolism and peripheral quantitative computed tomography (pQCT) measures of the mid-tibia in 15-year-olds from the Avon Longitudinal Study of Parents and Children. To examine associations between metabolic measures and periosteal circumference (PC), cortical thickness (CT), and cortical bone mineral density (BMD_C), ordinary least squares linear regression was used. In this investigation involving 1,121 subjects, the authors concluded that circulating levels of citrate were inversely related to BMD_C and positively related to PC in adolescents, reflecting associations with higher bone turnover.