Wang M, et al. - Researchers studied how dual source computed tomography perfusion imaging (CTPI) was correlated to microvascular parameters, as well as assessed the significance of CTPI in the differential diagnosis of solitary pulmonary nodule (SPN). Participants were 65 consecutive patients with SPN. CT perfusion imaging with dual source CT (computed tomography) was successfully performed prior to operation in these patients. A final diagnosis was made based on postoperative pathology. Considering pathological results, malignant, benign and inflammatory groups were defined. CTPI of SPNs was carried out to obtain CT perfusion parameters, such as blood flow, blood volume, mean transit time, and permeability surface. Not just the number of microvessels (microvessel density) but the degree of lumen or maturity of microvessels (luminal vascular number, luminal vascular area, and luminal vascular perimeter) primarily reflected blood perfusion of SPN. In the non-invasive assessment of tumor angiogenesis as well as in the differentiation of malignant SPNs from benign and inflammatory SPNs, the significance of CT perfusion imaging was shown.